Human multipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright,/CD34-/CD45 -/glycophorin-A- bone marrow cells

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Abstract

Magnetic and flow cytometry-based methods were used to characterize clonogenic stromal cells in human bone marrow. STRO-1bright stromal cells were found to lack expression of CD34, CD45 and glycophorin-A markers associated with hematopoietic progenitor cells. These studies support the view that these are two distinct stem cell compartments in adult bone marrow.

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Zannettino, A. C. W., Paton, S., Kortesidis, A., Khor, F., Itescu, S., & Gronthos, S. (2007). Human multipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright,/CD34-/CD45 -/glycophorin-A- bone marrow cells. Haematologica, 92(12), 1707–1708. https://doi.org/10.3324/haematol.11691

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