Glucose 6 phosphate dehydrogenase levels in babies delivered at the University of Ilorin teaching hospital.

Abstract

Glucosee66phosphateedehydrogenase levelssinnbabiessdelivereddatttheeUniversity offIlorinnteachingghospital. babies with normal enzyme levels were significantly higher than in male babies with normal enzyme levels (5.72 2.45 U/gHb versus 4.99 2.3 U/gHb, p = 0.002). Enzyme levels in babies with G6PD deficiency was comparable in both males and females (2.05 ± 0.60 u/gHb in females and 2.1 0.66 U/gHb in males, p = 0.66). The prevalence of G6PD deficiency was comparable among males and females (p = 0.81 = 0.06, RR = 1 . 0 2 , C I = 0 . 9 0 < R R < 1 . 1 5 , OR=1.04). There is a high prevalence of G6PD deficiency in babies delivered at the University of Ilorin Teaching Hospital, and the enzyme deficiency appears to occur equally among the sexes. Glucose6phosphate, neonates, cord blood + + + , χ 2 Conclusion: Abstract Glucose6phosphateedehydrogenase deficiency,,annXlinkeddrecessive disorder,,isstheemosttcommon enzymopathyyproducinggdisease innhumans.Ittissknownntoocause severeeneonatal hyperbilirubinaemia. To determine G6PD levels in babies delivered at the University of Ilorin Teaching H o s p i t a l w i t h a v i e w t o determining the prevalence of G6PD deficiency. Samples of cord blood were collected at delivery, from 933 babies who met set criteria. Blood was assayed for G6PD levels using a quantitative in vitro test (RANDOX©). A total of 348 (37.3%) of the 933 tested subjects had G6PD deficiency with enzyme activity of ≤ 2.8U/gHb. Glucose 6 Phosphate Dehydrogenase levels in female Background: