MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1

Abstract

Small non-coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the present study, the expression level of miR-181 was reduced in glioma tissues compared with the adjacent normal tissues. The enforced expression of miR-181 was able to inhibit cell proliferation in U251 and SHG-44 cells, while antisense miR-181 oligonucleotides (antisense miR-181) enhanced cell proliferation. At the molecular level, these results further revealed that the expression of cyclin B1, a positive cell-cycle regulator, was negatively regulated by miR-181. Therefore, the data reported in the present study demonstrates that miR-181 is an important regulator in glioma. These results may contribute to improving the understanding of the key misregulated miRNAs in glioma.