Erratum to: Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin (Obesity, (2014), 22, (2563-2569), 10.1002/oby.20900)

Abstract

The authors of the paper listed above recently identified an error in the measured resting metabolic rate (RMR) data in participants of “The Biggest Loser” competition (BLC) at 7 months. In Table 1, the corrected RMR at 7 months in BLC is (mean ± SD) 1967 ± 331 kcal/d such that there was a significant metabolic adaptation of -308 ± 165 kcal/d (P<0.0001) that was not significantly different from metabolic adaptation in Roux-en-Y gastric bypass surgery (RYBG) patients at 6 months (P=0.118). The corrected RMR at 7 months in BLC was significantly different from measured RMR in RYGB at 6 months (P<0.05). Figure 2 has been corrected below. Metabolic adaptation was significantly correlated with energy imbalance (r=0.72, P<0.0001), rate of weight loss (r=0.67, P=0.0002), and percent change in leptin (r=0.52, P=0.006) in combined BLC at 7 months and RYGB at 1 year. Similarly, when including RYGB data at 6 months, metabolic adaptation was significantly correlated with energy imbalance (r=0.62, P=0.0001), rate of weight loss (r=0.61, P=0.0001), and percent change in leptin (r=0.38, P=0.02). Figure 3 has been corrected below. Finally, the authors previously reported a non-significant association between metabolic adaptation and changes in T3; however, the corrected data demonstrate a trend for a positive association between metabolic adaptation and changes in T3 (r=0.48, P=0.06). The authors regret this error. (Figure presented.).