Rapid Recall Ability of Memory T cells is Encoded in their Epigenome

31Citations
Citations of this article
124Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Even though T-cell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both naïve and memory T cells, the memory cells are capable of producing lineage specific cytokines much more rapidly than the naïve cells. The mechanisms behind this rapid recall response of the memory cells are still not completely understood. Here, we performed epigenetic profiling of human resting naïve, central and effector memory T cells using ChIP-Seq and found that unlike the naïve cells, the regulatory elements of the cytokine genes in the memory T cells are marked by activating histone modifications even in the resting state. Therefore, the ability to induce expression of rapid recall genes upon activation is associated with the deposition of positive histone modifications during memory T cell differentiation. We propose a model of T cell memory, in which immunological memory state is encoded epigenetically, through poising and transcriptional memory.

Cite

CITATION STYLE

APA

Barski, A., Cuddapah, S., Kartashov, A. V., Liu, C., Imamichi, H., Yang, W., … Zhao, K. (2017). Rapid Recall Ability of Memory T cells is Encoded in their Epigenome. Scientific Reports, 7. https://doi.org/10.1038/srep39785

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free