Lung cancer detection and classification with 3D convolutional neural network (3D-CNN)

Abstract

This paper demonstrates a computer-aided diagnosis (CAD) system for lung cancer classification of CT scans with unmarked nodules, a dataset from the Kaggle Data Science Bowl 2017. Thresholding was used as an initial segmentation approach to segment out lung tissue from the rest of the CT scan. Thresholding produced the next best lung segmentation. The initial approach was to directly feed the segmented CT scans into 3D CNNs for classification, but this proved to be inadequate. Instead, a modified U-Net trained on LUNA16 data (CT scans with labeled nodules) was used to first detect nodule candidates in the Kaggle CT scans. The U-Net nodule detection produced many false positives, so regions of CTs with segmented lungs where the most likely nodule candidates were located as determined by the U-Net output were fed into 3D Convolutional Neural Networks (CNNs) to ultimately classify the CT scan as positive or negative for lung cancer. The 3D CNNs produced a test set Accuracy of 86.6%. The performance of our CAD system outperforms the current CAD systems in literature which have several training and testing phases that each requires a lot of labeled data, while our CAD system has only three major phases (segmentation, nodule candidate detection, and malignancy classification), allowing more efficient training and detection and more generalizability to other cancers.