Dementia and Adherence to Anti-Diabetic Medications: A Meta-Analysis

Abstract

Introduction Diabetes mellitus (DM) and dementia (DN) are common morbid disorders with high mortality, the two disorders shared the pathogenesis of proinflammation and insulin resistance. Polypharmacy is expected when DM and DN co-exist and medication adherence is essential to an effective self-care and management plan. This meta-analysis aimed to assess medication persistence among patients with diabetes and cognitive impairment (CogImp). Methods We systematically searched the literature through PubMed, Medline, Cochrane library, and the first 100 articles published in Google Scholar. We included articles publishes in English and conducted on humans, no limitation was set to the date of publication, all the articles were approached from the first published up to March 15, 2021. The keywords used were Dementia, cognitive impairment, cognitive decline, cognitive dysfunction, diabetes self-care, compliance to anti-diabetic drugs, and medication adherence. One hundred-seventy-six were identified, the 12 full texts screened, only four fulfilled the inclusion and exclusion criteria. Results The studies were published in Europe, the United States, and Asia (all were observational). The results showed no effects of dementia on medication adherence, P-value of 0.41, odd ratio: 1.09, 95% CI: 0.89-1.32, Chi-square for heterogeneity: 12.15, I2 = 75%, and standard difference = 3. The P-value for heterogeneity was 0.007. The studies included 2,556 patients and 1,854 events. Conclusion No association was found between dementia and compliance to anti-diabetic medications. Further prospective studies are needed to solve the issue.