Hypocholesterolaemic effects of fermented red onion (Allium cepa L. var aggregatum) in rats (Rattus novergicus)

Abstract

Red onion is known as one of spices, and it also benefits for human health evidently. Previous study that red onion has a beneficial for cardiovascular disease, including hypocholesterolaemic Red onion contains flavonoids. The extract of red onion decreased serum total cholesterol level of rats, which is mediated by quercetin. Quercetin could be increased by fermentation as one of the new methods in drug discovery, so the biological activity also increases through fermentation. This study aimed to antihypercholesterolaemic activity of red onion fermented extract. Twenty five rats were divided in 5 groups; 2 controls [negative and positive control (atorvastatin)] with treatment groups (100, 200 and 300 mg/kg bw of fermented red onion extract. Rats were given atherogenic feed until hypercholesterolaemic All groups were given an atherogenic feed until hypercholesterolaemic. Total cholesterol of rats measured on the 7th, 14th and 21st day after they rats were treated by red onion fermented extract. Data analysed by ANOVA and continued by post hoc Duncan. All doses of red onion fermented extract decreased total cholesterol level of rats and dose of 200 mg/kg showed the strongest effect. Write the expectation for future fermented red onion has potential as a new agent cardiovascular health.