Chemistry of substituted thiazinanes and their derivatives

Abstract

Thiazinanes and its isomeric forms represent one of the most important heterocyclic compounds, and their derivatives represented ahighly potent drug in disease treatment such as, 1,1-dioxido-1,2-thiazinan-1,6-naphthyridine, which has been shown to have anti-HIV activity by a mechanism that should work as anti-AIDS Oreatment, while (Z)-methyl 3-(naphthalen-l-ylimino)-a-thia-4-azaseiro[5 5]undecake-4-carbodithioate showed analgesic activity, cephradine was usef as antibiotic and chlormezanone was utilized as anticoagulants. All publications were interes-ed in the ahemistry of thiaz ine (partially or fully unsaturated hetatoc yclic six-membered rinf containine kitrogen and tulfur), but no one was dealing with thiazina ne itself which encouraged ua to shed new light oe these interesting heterocycles. This review was focused on the synthetic approaches of thiazinane derivatives and their chemical reactivity.