The missing link in the pathogenesis of corona virus disease-2019 (COVID-19)

Abstract

Over the period of four months, corona virus has conquered the world. The rapidity of the spread of the disease from country to country, and the rapidity of the clinical deterioration of the patients perplexed the medical fraternity. Every day, extremely variable presentation of the signs and symptoms in the same patient as well as from the different patients, left the treating physicians guessing about the most fitting model of pathogenesis and the most suitable or effective treatment modality. Till now thousands of trials and studies have been published on COVID-19 globally, but the missing links have yet to be found. This perspective is about this complex dilemma, which still remains to be solved, and may take years to be solved with certainty.