Stereoselectivity in the Reduction of Cyclic Ketones with Sodium Borohydride. Effect of the Ratio of the Components of a Mixed Solvent of Tetrahydrofuran and Methanol

Abstract

Reduction of relatively conformationally rigid cyclic ketones with sodium borohydride was examined in a mixed solvent of tetrahydrofuran(THF) and methanol(MeOH) with varying the ratio of the components. The highest stereoselectivities of the reductions were observed in the mixed solvent, and not in each individual solvent.