Early exercise training after renal transplantation and asymmetric dimethylarginine: The effect of obesity

Abstract

Results: There were no significant differences in ADMA levels between both groups before the training program (Group IB vs Group IIB). After six months of exercise, ADMA levels in Group I decreased (Group IB vs Group IA: 3.50 ± 0.45 vs 2.11 ± 0.35μmol/L; p< 0.01) and were lower compared to those in Group II (Group IA vs Group IIA: 2.11 ± 0.23 vs 3.25 ± 0.34μmol/L; p< 0.01). Analysis of our results in obese renal transplant recipients (BMI > 30 kg/m2) confirmed a smaller effect of exercise training (Group IBO vs Group IAO : 3.75 ± 0.52 vs 3.45 ± 0.45; p< 0.05 and Group IAO vs Group IIAO: 3.45 ± 0.45 vs 3.74 ± 0.62; p<0.05). Blood lipids, HbA1c, insulin, and systolic BP were also affected by the training program. Conclusion: Elevated ADMA levels were significantly decreased by early exercise after renal transplantation. The effect of exercise was smaller in obese patients. Methods: Blood samples before and after six months were obtained from 116 transplant patients participating in an aerobic exercise (Group I). A control group consisted of 122 matched transplant patients who did not exercise regularly (Group II). Background/Aims: To assess, in a prospective cohort study of 238 renal transplant patients, our hypothesis that elevated ADMA levels may be influenced by physical exercise and obesity.