Quality over Quantity: A Case Based Review of HDL Function and Dysfunction

Abstract

High density lipoprotein cholesterol (HDL) has traditionally been considered athero-protective and has been associated with a reduced risk of atherosclerotic cardiovascular disease (ASCVD). This has led to an approach of increasing HDL levels in high risk patients. However, due the complexity of the HDL particle and its diverse role in inflammation and immunity, this simple approach may be detrimental to cardiovascular health.