Chemical constituents from the root bark of calophyllum inophyllum

Abstract

A new chromanone derivative, namely caloinophyllin B (1), along with seventeen known compounds 2-18 were isolated from the root bark of Calophyllum inophyllum. The structures of all isolated compounds (1-18) were determined by spectroscopic methods as well as comparison with previous reports in the literature. To the best of our knowledge, compounds 1, 3, 6, 8, 11-14 and 16 were isolated from this plant for the first time. Moreover, all isolated compounds (1-18) were evaluated for their cytotoxicity against KB and Hela S-3 cell lines. Compound 8 exhibited moderate activity toward KB and Hela S-3cells with the IC50 values of 25.8 and 18.1μM, respectively.