We investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentrations of fat fuels (triglycerides and non-esterified fatty acids) were either unchanged or slightly higher after rats tasted a preferred sweet taste solution (0.125% saccharin +3% glucose) than after they tasted water. They were markedly lower after rats tasted a non-preferred solution-either a bitter solution (0.15% quinine hydrochloride) or a sweet solution that had previously been the conditioned stimulus for lithium-induced taste aversion. The distribution of 14C-triolein mixed with the gastric load was determined at 4 h postinfusion. Rats that received a non-preferred bitter taste had significantly more 14C remaining in the stomach than did those that received a preferred sweet taste. These results suggest that taste hedonics-either unconditioned or conditioned aversive tastes-influence fat disposition by altering gastric emptying. © 2014 Saitou et al.
CITATION STYLE
Saitou, K., Lees, J. N., & Tordoff, M. G. (2014). Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. PLoS ONE, 9(3). https://doi.org/10.1371/journal.pone.0090717
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