Glial Fibrillary Acidic Protein: Regulation by Hormones, Cytokines, and Growth Factors

210Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Levels of glial fibrillary acidic protein (GFAP), an astrocyte‐specific intermediate filament protein, are altered during development and aging, GFAP also responds dynamically to neurodegenerative lesions. Changes in GFAP expression can occur at both transcriptional and translational levels. Modulators of GFAP expression include steroids, cytokines, and growth factors. GFAP expression also shows brain region‐specific responses to sex steroids and of astrocyte‐neuronal interactions. The 5′‐upstream sequences of rat, mouse, and human are compared for the presence of response elements that are candidates for transcriptional regulation of GFAP. We propose that the regulation of the GFAP gene has evolved a system of controls that allow integrated responses to neuroendocrine and inflammatory modulators. Copyright © 1994, Wiley Blackwell. All rights reserved

Cite

CITATION STYLE

APA

Laping, N. J., Teter, B., Nichols, N. R., Rozovsky, I., & Finch, C. E. (1994). Glial Fibrillary Acidic Protein: Regulation by Hormones, Cytokines, and Growth Factors. In Brain Pathology (Vol. 4, pp. 259–275). https://doi.org/10.1111/j.1750-3639.1994.tb00841.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free