Pineal melatonin and related indoles levels were higher in Roman high- than in Roman low-avoidance rats, while 5-HIAA/5-HT ratio, as an index of MAO activity was higher in low- than in high-avoidance rats. Clorgyline stimulated pineal melatonin biosynthesis in both lines of rats. However, melatonin and N-acetylserotonin levels remained higher and 5-HIAA levels remained lower in the high avoidance rats treated with low dose (0.5 mg/kg) while treatment with 1.0 mg/kg of clorgyline eliminated the differences in melatonin production between high- and low-avoidance rats.
CITATION STYLE
Requintina, P. J., Driscoll, P., & Oxenkrug, G. F. (1994). Clorgyline effect on pineal melatonin biosynthesis in Roman high- and low- avoidance rats. In Journal of Neural Transmission, Supplement (pp. 145–148). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-9324-2_20
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