In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
CITATION STYLE
Oliveira, F. M. de, Souza, V. G. de, Carvalho, A. de L., Lizarte Neto, F. S., & Miranda, C. S. S. (2023). Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report. Einstein (Sao Paulo, Brazil), 21, eRC0378. https://doi.org/10.31744/einstein_journal/2023RC0378
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