Síndrome da ceratomalácia (Corneal Melting) periférica na artrite psoriásica tratada com adalimumabe

Abstract

Peripheral corneal melting syndrome is a rare immune condition characterized by mar-ginal corneal thinning and sometimes perforation. It is associated with rheumatic andnon-rheumatic diseases. Few cases of peripheral corneal melting have been reported in pati-ents with psoriasis. The pathogenesis is not fully understood but metalloproteinases mayplay a pathogenic role. Anti-TNF therapy has shown to decrease skin and serum metallo-proteinases levels in psoriasis. We report a 61-year-old man with peripheral corneal meltingsyndrome associated with psoriatic arthritis who received Adalimumab to control skin and ocular inflammation. To our knowledge, this is the first case report of peripheral corneal melting syndrome in psoriatic arthritis treated with Adalimumab showing resolution of skin lesions and complete healing of corneal perforation in three months.