Formulation and stability test of cream ethanol extract senduduk leaves (Melastoma malabatricum l.) on burn healing of male white mice

Abstract

Burns are tissue damage caused by contact with heat sources such as fire, chemicals, electricity and radiation. This study aims to find a new burn drug from senduduk leaves (Melastoma malabathricum L.) with a form of standard cream preparation type M/A. The viscous extract of the leaves of senduduk is carried out by a characterization test and screening test, then formulated in the form of cream with a concentration of 2.5%, 5%, and 7.5%. Standard cream type M/A formulated with senduduk leaf extract was evaluated and tested for the stability of the preparation. Mice were burnt with a heated metal plate, then smeared with the cream of senduduk leaf extract and the diameter was measured using a calliper by measuring the four sides of the wound diameter and averaging it to obtain the proportion of wound closure. The percentage of wound closure was analyzed at D-1 to D-11 treatment. The results showed that the ethanol extract of senduduk leaf cream preparation with a concentration of 7.5% was more effective in healing burns with an average diameter of 0.20 cm of final burns and the proportion of wound healing was 99% compared to the concentration of senduduk leaf extract cream preparation which was other. The results of the burn test showed that the ethanol extract of senduduk leaf cream with a concentration of 7.5% was efficacious in healing wounds in mice.