Mechanotransduction in Wound Healing and Scar Formation

Abstract

Scarring is the typical response to tissue injuries and the process of fibrotic repair provides early restoration of tissue integrity rather than functional regeneration. Effective clinical therapies for scar mitigation are only beginning to be developed. The author discusses molecular biomechanics of scar formation, extracellular mechanotransduction (mechanisms by which mechanical forces are converted to biochemical stimuli), intracellular mechanotransduction, and modulation of cutaneous biomechanics to reduce scarring. A profound understanding of the biomechanical principles influencing scarring and fibrosis is imperative to combat this significant pathology that represents a substantial healthcare burden worldwide.