Researching Individual Satisfaction with Group Decisions in Tourism: Experimental Evidence

Abstract

We have evaluated the feasibility of using a mathematical model ofglucose disappearance to estimate insulin sensitivity. Glucose wasinjected into conscious dogs at 100, 200, or 300 mg/kg. The measuredtime course of insulin was regarded as the ``input,'' and the fallingglucose concentration as the ``output'' of the physiological systemstoring and using glucose. Seven mathematical models of glucose uptakewere compared to identify the representation most capable of simulatingglucose disappearance. One specific nonlinear model was superiorin that it 1) predicted the time course of glucose after glucoseinjection, 2) had four parameters that could be precisely estimated,and 3) described individual experiments with similar parameter values.Insulin sensitivity index (SI), defined as the dependence of fractionalglucose disappearance on plasma insulin, was the ratio of two parametersof the chosen model and could be estimated with good reproducibilityfrom the 300 mg/kg injection experiments (SI = 7.00 X 10(-4) +/-24% (coefficient of variation) min-1/(microU/ml) (n = 8)). Thus,from a single glucose injection it is possible to obtain a quantitativeindex of insulin sensitivity that may have clinical applicability.