Cryoglobulinemia

Abstract

Cryoglobulinemia (CR) is a disease characterized by the presence, in the serum, of abnormal proteins that precipitate reversibly at low temperatures, and generally the cryoglobulins lead to a systemic inflammatory syndrome characterized by myalgia, arthralgia, purpura (Meltzer's triad), neuropathy, and glomerulonephritis [1]. According to immunochemical characteristic, cryoglobulins have been classified into 3 distinct groups:.