Comparison of spin-echo T1- and T2-weighted and gradient-echo T1-weighted images at 3T in evaluating very preterm neonates at term-equivalent age

Abstract

Term-equivalent imaging can assess myelination status in very preterm infants (<30 weeks' gestational age at birth). However, myelination assessment has yet to be compared among GRE-T1WI, SE-T1WI, and SE-T2WI at 3T. We aimed to compare the rates of myelination among those 3 sequences in 11 very preterm neonates who underwent 3T MR imaging at term-equivalent age and subsequently had normal neurologic development. On each sequence, 2 neuroradiologists individually assessed 22 structures. SE-T2WI depicted a higher myelination rate (present in 58.2%- 66.4% of all structures) than either GRE-T1WI (51.6%- 63.9%) or SE-T1WI (20.5%-38.5%), while GRE-T1WI had the highest interobserver agreement (κ, 0.56; P