Among 104 cases of squamous-cell oesophageal carcinoma patients and 277 controls in Taiwan, after adjusting for cigarette smoking, alcohol consumption, and other confounders, we found that subjects who chewed from 1 to 495 betel-year and more than 495 betel-years (about 20 betel quid per day for 20 years) had 3.6-fold (95% Cl=1.3-10.1) and 9.2-fold risk (95% Cl=1.8-46.7), respectively, of developing oesophageal cancer, compared to those who did not chew betel. © 2001 Cancer Research Campaign.
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Wu, M. T., Lee, Y. C., Chen, C. J., Yang, P. W., Lee, C. J., Wu, D. C., … Lee, J. M. (2001). Risk of betel chewing for oesophageal cancer in Taiwan. British Journal of Cancer, 85(5), 658–660. https://doi.org/10.1054/bjoc.2001.1927