Orchestrated efforts on host network hijacking: Processes governing virus replication

17Citations
Citations of this article
45Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely “autophagy”, “programmed cell death”, “immune response”, “cell cycle alteration”, and “lipid metabolic reprogramming”, that considerably guide viral replication after host infection in an orchestrated manner. On viral infection, “autophagy” and “programmed cell death” are two dynamically synchronized cell survival programs; “immune response” is a cell defense program typically suppressed by viruses; “cell cycle alteration” and “lipid metabolic reprogramming” are two altered cell housekeeping programs tunable in both directions. We emphasize on their functionalities in modulating viral replication, strategies viruses have evolved to tune these processes for their benefit, and how these processes orchestrate and govern cell fate upon viral infection. Understanding how viruses hijack host networks has both academic and industrial values in providing insights toward therapeutic strategy design for viral disease control, offering useful information in applications that aim to use viral vectors to improve human health such as gene therapy, and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.

Cite

CITATION STYLE

APA

Dai, X., Hakizimana, O., Zhang, X., Kaushik, A. C., & Zhang, J. (2020, January 1). Orchestrated efforts on host network hijacking: Processes governing virus replication. Virulence. Taylor and Francis Inc. https://doi.org/10.1080/21505594.2020.1726594

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free