Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi

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Abstract

Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi.

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Ravaschino, E. L., Docampo, R., & Rodriguez, J. B. (2003). Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi. Arkivoc, 2003(10), 298–313. https://doi.org/10.3998/ark.5550190.0004.a28

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