Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide1)

Abstract

a-Rat atrial natriuretic peptide (7—28) (rANP (7—28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid-phase method followed by cyclization by means of dimethylsulfoxide (DMSO)-trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7—28). © 1993, The Pharmaceutical Society of Japan. All rights reserved.