Immunomodulation of EAE: Altered peptide ligands, tolerance, and Th1/Th2

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an animal model for human multiple sclerosis (MS). The disease is initiated by myelin-specific T cells, but mediated by cells of both the adaptive and innate immune system. Therefore, strategies targeting either lymphocytes or myeloid cells can be effective in modulating EAE. In this chapter, we will review some of the strategies that have been developed to treat or prevent EAE. Our emphasis will be on those strategies that are still in the developmental stage, but may have the potential to be used in the clinic in the future.