Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro

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Abstract

Objectives: To explore the potential application of B-OT in the aspiration tract. Materials and Methods: We conceived and optimized an in vitro model simulating the mouth-washing process to assess tolerance to B-OT on primary human gingival fibroblasts. Cells derived from 4 unrelated donors were flushed with medium containing drugs of various concentration for one minute twice daily for 3 days. Results: No effect was seen on the cells up to 1000 µM B-OT. In addition, we treated the cells with B-OT permanently in medium, corresponding to a systemic treatment. No effect was seen by 10 µM B-OT and only a slight reduction (approximately 10%) was seen by 100 µM B-OT. Conclusions: Our results suggest good tolerance of oral cells for B-OT, favoring the further development of this antiviral reagent as a mouth-washing solution and nasal spray.

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Yan, M., Smeets, R., Gosau, M., Vollkommer, T., Fuest, S., Stetzer, E., … Burg, S. (2022). Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro. International Journal of Environmental Research and Public Health, 19(7). https://doi.org/10.3390/ijerph19074112

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