The history of pharmacologic vitreolysis

Abstract

Pharmacologic vitreolysis is an evolving therapeutic modality with increasing actual or potential applications and a relatively short history. Prior to the introduction of vitrectomy in the early 1970s [1], the vitreous was regarded by most ophthalmologists as sacrosanct and not amenable to therapeutic intervention. However, owing to the expansion of our understanding of the composition and organization of the vitreous on a molecular level and how aging as well as disease affect this delicate homeostasis, we now have enough information to engender the courage to broach this subject.