Stochastic k-tree grammar and its application in biomolecular structure modeling

Abstract

Stochastic context-free grammar (SCFG) has been successful in modeling biomolecular structures, typically RNA secondary structure, for statistical analysis and structure prediction. Context-free grammar rules specify parallel and nested co-occurren-ces of terminals, and thus are ideal for modeling nucleotide canonical base pairs that constitute the RNA secondary structure. Stochastic grammars have been sought, which may adequately model biomolecular tertiary structures that are beyond context-free. Some of the existing linguistic grammars, developed mostly for natural language processing, appear insufficient to account for crossing relationships incurred by distant interactions of bio-residues, while others are overly powerful and cause excessive computational complexity. This paper introduces a novel stochastic grammar, called stochastic k-tree grammar (SkTG), for the analysis of context-sensitive languages. With the new grammar rules, co-occurrences of distant terminals are characterized and recursively organized into k-tree graphs. The new grammar offers a viable approach to modeling context-sensitive interactions between bioresidues because such relationships are often constrained by k-trees, for small values of k, as demonstrated by earlier investigations. In this paper it is shown, for the first time, that probabilistic analysis of k-trees over strings are computable in polynomial time nO(k). Hence, SkTG permits not only modeling of biomolecular tertiary structures but also efficient analysis and prediction of such structures. © 2014 Springer International Publishing.