Abstract
Exposure to ultraviolet radiation (UV) is the main factor related to skin cancer making the sunscreen an efficient prevention of this disease. Lapachol is a natural naphthoquinone found in some plant species which is capable of absorbing UV. Eight derivatives of lapachol were prepared by semi-synthesis and sun protection factors (SPF) against UVB radiation were determined using the spectrophotometric method developed by Mansur. The oximes derived from lapachol 5, 7, 8 and 9 showed significant photoprotective potential with SPF-UVB of 11,05 ± 0,41, 9,67 ± 0,30, 10,12 ± 0,22 e 7,18 ± 0,15, respectively, at the concentration of 1.0 × 10-4 M.
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Araújo, C. R. M., Santos, V. L. A., Guimarães, D. G., De Oliveira, R. G., Da Silva Almeida, J. R. G., & Gonsalves, A. A. (2014). Synthesis and in vitro determination of SPF-UVB oximes derived from lapachol. Revista Virtual de Quimica, 6(6), 1702–1712. https://doi.org/10.5935/1984-6835.20140110
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