Effect of a booster-dose of rabies vaccine on the duration of virus neutralizing antibody titers in bovines

Abstract

Humoral immune response using inactivated rabies vaccine was studied in 35 nelore cross-bred bovines of western region of Sao Paulo state. Ninety days after vaccination, 13 (92.8%) animals presented titers ≤ 0.5lU/ml, through mouse neutralization test. After 180 days, 9 (64.3%) sera showed titers ≤ 0.5lU/ml, after 270 days, only one (7.1%) showed a titer of 0.51lU/ml, and after 360 days, all animals showed titers < 0.5lU/ml. Group of animals receiving booster dose 30 days after vaccination presented, two months after, all with titers > 0.5lU/ml. At 180 days, 17 (80.9%) sera presented titers > 0.5lU/ml; at 270 days, 15 (71.4%), with titers ≤ 0.5lU/ml and at 360 days, 4 (19.0%), with titers ≤ 0.5lU/ml. Booster-dose ensured high levels of neutralizing antibodies for at least three months, and 240 days after revaccination, 71.4% of animals were found with titers ≤ 0.5lU/ml.