How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.
CITATION STYLE
Cunningham, K. L., & Littleton, J. T. (2019). Neurons regulate synaptic strength through homeostatic scaling of active zones. Journal of Cell Biology, 218(5), 1434–1435. https://doi.org/10.1083/jcb.201903065
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