Pathology of Vogt-Koyanagi-Harada disease

Abstract

Typical histopathologic features of Vogt-Koyanagi-Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalén'Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium. © Springer Science+Business Media, Inc. 2007.