Core Fucosylation of N-Linked Glycan for Fine-Tuning TGF βReceptor Function

Abstract

Core fucosylation of glycans regulate diverse biological functions through the modification of targeting proteins, such as TGF-β receptors, EGF receptor, integrin, VEGF receptor, and immunoglobulin mu heavy chain. In the TGF-β signaling transduction, fine-tuning of core fucosylation of on TGF-β receptor amplified the biological effects of this pathway in the lung and kidney and neurite outgrowth. Significant alterations of pathology and physiology were observed in both animal and cell models.