Carbohydrate (N-Acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 (CHST15)

Abstract

Chondroitin/dermatan sulfate contains GlcAβ1-3GalNAc(4, 6-bissulfate)β1-4 or IdoA α1-3GalNAc(4, 6-bissulfate)β1-4 repeating units at varying proportion depending on the biological sources of the glycosaminoglycans. Chondroitin sulfate (CS) containing this repeating unit was initially found in the cartilage of squid and named as CS-E. CS-E was found in vertebral cells and tissues such as mast cells or brain. Dermatan sulfate (DS) containing this repeating unit was found in mammalian organs such as liver, kidney, or spleen. N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is a sole enzyme that transfers sulfate to position 6 of GalNAc 4-sulfate residues of CS/DS and produces GlcAβ1-3GalNAc(4, 6-bissulfate)β1-4 or IdoA α1-3GalNAc(4, 6-bissulfate)β1-4 repeating units.