The effect of a high-fat breakfast on the pharmacokinetics of moxidectin in healthy male subjects: A randomized phase I trial

Abstract

The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C max: 58.9 [12.5] ng/mL; t max: 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ z /F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t 1/2: 784 [347] h. Compared with fasted subjects, fed subjects (N = 27) exhibited a 34% increase in C max, delay in t max to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ z /F, and a 35% decrease in CL/F. There was no significant change in t 1/2. The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.