Minocycline inhibits Candida albicans budded-to-hyphal-form transition and biofilm formation

15Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Candida albicans frequently causes bloodstream infections; its budded-to-hyphal-form transition (BHT) and biofilm formation are major contributors to virulence. During an analysis of antibacterial compounds that inhibit C. albicans BHT, we found that the tetracycline derivative minocycline inhibited BHT and subsequent biofilm formation. Minocycline decreased expression of hypha-specific genes HWP1 and ECE1, and adhesion factor gene ALS3 of C. albicans. In addition, minocycline decreased cell surface hydrophobicity and the extracellular β-glucan level in biofilms. Minocycline has been widely used for catheter antibiotic lock therapy to prevent bacterial infection; this compound may also be prophylactically effective against Candida infection.

Cite

CITATION STYLE

APA

Kurakado, S., Takatori, K., & Sugita, T. (2017). Minocycline inhibits Candida albicans budded-to-hyphal-form transition and biofilm formation. Japanese Journal of Infectious Diseases, 70(5), 490–494. https://doi.org/10.7883/yoken.JJID.2016.369

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free