Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies

Abstract

Idiopathic inflammatory myopathies (IIM), also referred to as “myositis,” are a group of heterogeneous autoimmune disorders characterised by muscle weakness, atrophy and progressive reduced mobility (Lundberg et al , 2021). IIM represent a significant health burden in adult populations, affecting individuals at a mean age of 50 with an estimated prevalence of 2.9–34 per 100,000 (Dobloug et al , 2015; Svensson et al , 2017). IIM encompass several subtypes including dermatomyositis, immune‐mediated necrotising myopathy, inclusion‐body myositis, antisynthetase syndrome and polymyositis, which are characterised by specific clinical features, histopathological findings and autoantibody status (Pinal‐Fernandez et al , 2020).