Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group

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Abstract

A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no loss of enantiomeric excess. The methodology is exemplified by a new synthesis of enantiopure praziquantel, the drug used in the treatment of millions of people suffering from the neglected tropical disease, schistosomiasis. © 2013 The Royal Society of Chemistry.

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Tsang, A. S. K., Ingram, K., Keiser, J., Hibbert, D. B., & Todd, M. H. (2013). Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic and Biomolecular Chemistry, 11(30), 4921–4924. https://doi.org/10.1039/c3ob40503f

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