The adaptation of Hi-C protocols to enable the investigation of chromosome organization in single cells opens new avenues to study the dynamics of this process during embryogenesis. However, the analysis of single-cell Hi-C data is not yet standardized and raises novel bioinformatic challenges. Here we describe a complete workflow for the analysis of single-cell Hi-C data, with a main focus on allele-specific analysis based on data obtained from hybrid embryos.
CITATION STYLE
Collombet, S., Pérez-Rico, Y. A., Ancelin, K., Servant, N., & Heard, E. (2021). Bioinformatic analysis of single-cell Hi-C data from early mouse embryo. In Methods in Molecular Biology (Vol. 2214, pp. 295–316). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0958-3_20
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