Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases

Abstract

Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review we explore the recent discoveries in autophagy and how these relate to the special conditions experienced by the gut mucosa. We will pay particular attention to autophagy as an innate immune process and its role in the development and education of the adaptive immune system. Copyright © 2009 Crohn's & Colitis Foundation of America, Inc.