Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection

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Abstract

A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.

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Dukova, O. A., Kotlovsky, M. Y., Pokrovsky, A. A., Suvorova, E. V., Shivrina, T. G., Krasnov, E. A., & Efremov, A. A. (2016). Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection. Biomeditsinskaya Khimiya, 62(3), 325–330. https://doi.org/10.18097/PBMC20166203325

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