file:///Users/mayuka/Desktop/Mendeley/TGR5英語文献.pdfBile acids exert anti-obesity and anti-hyperglycemic effects through a G protein-coupled receptor TGR5. In L cells located in the lower small intestine TGR5 activation stimulates secretion of a peptide hormone GLP-1 that enhances insulin sensitivity. In brown adipose tissues and skeletal muscles its activation results in an increase in energy expenditure, leading to anti-obesity effects. Based on these findings, we searched for food factors that mimic bile acid functions, and identified a citrus limonoid nomilin as a powerful agonist for TGR5. Simulation -35
CITATION STYLE
Sato, R. (2016). Extension of healthy life expectancy through activation of the bile acid receptor TGR5. Journal of Lipid Nutrition, 25(1), 35–42. https://doi.org/10.4010/jln.25.35
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