Predictors of Vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective Retrospective Study

Abstract

AIM To identify the predictors of Vitamin D deficiency in patients with and without inflammatory bowel disease (IBD). METHODS Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyVitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had Vitamin D concentration checked. Logistic regression analysis was performed to determine the association between Vitamin D deficiency and UC, CD, race, age, gender and body mass index (BMI). RESULTS We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have Vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI > 30 kg/m2 (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be Vitamin D deficient than Vitamin D sufficient. Those with Age > 65 were more likely to be Vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with Vitamin D deficiency. CONCLUSION BMI > 30 kg/m2 and AA race are predictive of Vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of Vitamin D deficiency.