Estrogen Exposure and its influence in DNA Repair Genetic Variants in Breast Cancer Population

Abstract

The life time exposure to estrogen hormone and the family history describes the risk factors involved inhormone based life events in breast cancer population. Focusing the preventive strategies of breast cancer on genetic and epigenetic basis is pivotal. Aim: To explore the association of genetic base of reproductive factors and positive family history with genetic variants in breast cancer DNA repair genes. We conducted the study among 150 females in three groups, each comprising of 50 based on the selection criteria. The reproductive and hereditary risk factors are used as an outcome measure, which includes age >50 years, increased menstrual age, post-menopausal women, first full term pregnancy (FFTP)>30yrs, nulliparity, obesity, family history of breast cancer. The Genetic analysis is carried for four single nucleotide polymorphisms namely XRCC1 Arg 194 Trp, XRCC3 Thr 242 Met,ERCC4 Arg 415 Gln,, ERCC5 Asp 1104 His and the results are associated with outcome variables. To encapsulate 34% of females with positive family history are associated with XRCC1 R/W, 8% of females with obesity are associated with ERCC4 R/Q, 11% of females with FFTP>30yrs of age are associated with XRCC3 T/M, 24% of nulliparous women, 26% of females with increased menstrual age, 22 % of postmenopausal women, and 23% of females with age >50 years are associated with ERCC5 D/H. The results suggested the association of the reproductive risk factors of breast cancer with the single nucleotide polymorphism status of DNA repair genes and recommends future researches to have a more precise outcome.