Hepatoprotective and antidyslipidemic effect of Ferula asafoetida in CCl4 induced hepatotoxicity and CCl4 associated dyslipidemia in rats

Abstract

Objective: The present study was conducted to evaluate hepatoprotective and antidyslipidemic activity of aq. ext. of Ferula asafoetida in CCl4 induced hepatotoxicity and assocd. dyslipidemia and oxidative stress in rats. Material and methods: Hepatotoxicity was induced by administration of CCl4(1mg/kg) in alternate days for a period of 14 days. The animals were divided into 6 groups and aq. ext. of F. asafoetida at dose level of 50mg/kg, 100 mg/kg and 200 mg/kg was administered resp. for 21 days. Liv-52 (1ml/kg) was used as the std. drug. At the end day of the expt., the blood was collected by retro-orbital puncture and the hepatoprotective effect was evaluated by analyzing biochem. parameters involved in liver damage. Result: The ext. was effective in protecting the liver against the injury induced by CCl4 in rats. This was evident from significant redn. in serum glutamic-pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT) and total bilirubin content. The ext. revealed antioxidant and antihyperlipidemic activity too. Conclusion: It was concluded from the result that the aq. ext. of asafoetida possesses hepatoprotective activity against CCl4 induced hepatotoxicity in rats and also play a beneficial role in CCl4 assocd. dyslipidemia and status of oxidative stress. [on SciFinder(R)]