Comparison of treated mean intraocular pressure in stable glaucoma with different severity in vietnam

Abstract

Purpose: To compare stable glaucoma with different severity in a Vietnamese population in regard to mean intraocular pressure (IOP) and number of medications used.Materials and methods: A total of 116 eyes from 68 patients with medically treated glaucoma were prospectively enrolled at a single center and subjected to automated perimetry every 3 months for at least 9 months. Glaucoma progression was identified according to early manifest glaucoma trial criterion using glaucoma progression analysis software. Eyes in which no progression was identified were staged for glaucoma severity using field criteria (mild MD ≥ 6 dB, moderate MD -6 to -12 dB, advanced MD ≤12 dB, end-stage central island only). Groups were compared in terms of mean IOP and number of medications used. Statistical analysis was performed using SPSS v16.0.Results: A total of 109 eyes displayed no evidence of progression during the study period. Pretreatment mean IOP for mild, moderate, severe and end-stage glaucoma was 28.2 ± 1.4, 28.8 ± 1.6, 29.1 ± 1.8, and 28.6 ± 0.8 mm Hg. The mean IOP of all 109 eyes during follow-up was 16.8 ± 1.4 mm Hg (95% confidence interval = 15.4 ± 18.2 mm Hg). Mild, moderate, advan­ced, and end-stage glaucoma had mean IOP of 17.5 ± 1.2, 16.9 ± 1.3, 15.8 ± 0.9 and 15.5 ± 1.1 mm Hg. The mean IOP of mild stage was significantly higher than advanced and end-stage (t-test, p < 0.001). Also, the mean IOP of moderate glaucoma was significantly higher than advanced and end-stage glaucoma (t-test, p < 0.05). Number of medications had no significant difference among these glaucoma stages (chi-square test, p > 0.05). Conclusion: Reached IOP lowering contributes to glaucoma stabilization especially in late stages. To maintain stable glaucoma, there was no difference in medical procedure of glaucoma stages.